Different types of antidepressants work in their way to help balance chemicals in the brain and improve mood. The choice of which one to use often depends on the specific symptoms, any underlying conditions and how the individual responds to treatment. Doctors carefully consider these factors to find the most suitable medication for each patient.
Selective Serotonin Reuptake Inhibitors (SSRIs)
SSRIs are the most commonly prescribed type of antidepressant. They work by increasing the levels of serotonin, a neurotransmitter that influences mood, in the brain. Common SSRIs in the UK include fluoxetine (Prozac), sertraline (Lustral), citalopram (Cipramil) and escitalopram (Cipralex). These medications are often the first line of treatment due to their relatively mild side effect profile.
Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)
SNRIs increase the levels of both serotonin and norepinephrine, another neurotransmitter linked to mood and energy levels. SNRIs may be prescribed when SSRIs are not effective. Common examples in the UK include venlafaxine (Efexor) and duloxetine (Cymbalta).
Tricyclic Antidepressants (TCAs)
TCAs are an older class of antidepressants that affect multiple neurotransmitters, including serotonin and norepinephrine. While effective, they often have more side effects compared to SSRIs and SNRIs, so they are usually prescribed when newer antidepressants don’t work. Examples of TCAs in the UK include amitriptyline, imipramine (Tofranil) and nortriptyline (Allegron).
Other antidepressants
There are also other types of antidepressants that don’t fit neatly into these categories. For example, bupropion (Zyban), commonly used for smoking cessation, can also be effective as an antidepressant. Another example is agomelatine (Valdoxan), which affects melatonin receptors and is used to treat major depressive episodes with a focus on circadian rhythm regulation.